PhD Candidate and T32 fellow
My work is characterizing the mechanisms of neuroprotection by caloric restriction (CR), a model of delayed aging. Recently, our lab has established that CR induces a distinct state of energy metabolism in the hippocampus that is associated with reduced levels of GSK-3β, a nutrient-sensitive kinase that is known to participate in neurodegeneration. Additionally, we have demonstrated that GSK-3β negatively regulates the activity and stability of PGC-1a, a critical regulator of energy metabolism. We are now working to directly determine the role of GSK-3β in neuronal energy metabolism both at the cellular level, and in specific regions of the brain that are sensitive to neurodegeneration. This will allow us to better understand the principle factors that underlie age-related cognitive impairment.
Josef Clark, PhD
Postdoctoral T32 Fellow
Josef was a former Associate Research Specialist with Dr. Anderson from 2007 to 2011, whose work focused on the role of metabolism in tumor aggression in cancer. In his recent return to the lab as a postdoctoral fellow, Josef is focusing on how different RNA based mechanisms of gene regulation change in response to Aging and CR.
Anne Schaar, PhD
Postdoctoral Research Associate
Anne’s work focuses on the metabolic and functional changes in skeletal muscle due to aging. Currently, her research utilizes a small molecule adiponectin receptor agonist to investigate whether altering PGC1a can offset the effects of sarcopenia. Models used in her research include primary cells, mice, and non-human primates. Anne received her Ph.D. in Biochemistry and Molecular Biology from the University of North Dakota in 2018 and joined Dr. Anderson’s laboratory shortly after.
Samantha Wright, PhD
Sam’s research focuses on neuroscientific aspects of calorie restriction (CR), cellular metabolism and aging. Specifically, her experiments include imaging of NADH redux metabolism, investigation of beta amyloid plaques with multi photon imaging and immunohistochemistry in murine and primate brains; as well as investigation of CR effects on aging, longevity and vitality in mice. Her focus is on how neurons and neuronal systems adapt to altered metabolism in healthy and diseased states.
Timothy Rhoads, PhD
My work focuses on using various high-throughput molecular profiling techniques, such as RNA-Seq and proteomics, and systems biology approaches to understand aging and metabolism. I am specifically investigating the early molecular response to caloric restriction in rhesus macaques from the Wisconsin National Primate Research Center’s long-running Aging and Caloric Restriction study. I received my Ph. D. from Oregon State University in 2012, and spent four years as a postdoc with Dr. Josh Coon here at the University of Wisconsin before joining Dr. Anderson’s laboratory.
Dr. Rhoads’ publications on PubMed.